A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

by Laura M. Alcântara, Thalita C. S. Ferreira, Vanessa Fontana, Eric Chatelain, Carolina B. Moraes, Lucio H. Freitas-Junior
Published 2020-05-01

An image analysis algorithm for malaria parasite stage classification and viability quantification.

by Seunghyun Moon, Sukjun Lee, Heechang Kim, Lucio H Freitas-Junior, Myungjoo Kang, Lawrence Ayong, Michael A E Hansen
Published 2013-01-01

An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes.

by Min-Je Ku, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H Freitas-Junior
Published 2012-01-01

An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi.

by Seunghyun Moon, Jair L Siqueira-Neto, Carolina Borsoi Moraes, Gyongseon Yang, Myungjoo Kang, Lucio H Freitas-Junior, Michael A E Hansen
Published 2014-01-01

Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum.

by Carolina B Moraes, Thierry Dorval, Mónica Contreras-Dominguez, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lucio H Freitas-Junior
Published 2013-01-01

An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages.

by Jair L Siqueira-Neto, Seunghyun Moon, Jiyeon Jang, Gyongseon Yang, Changbok Lee, Hong Kee Moon, Eric Chatelain, Auguste Genovesio, Jonathan Cechetto, Lucio H Freitas-Junior
Published 2012-01-01

Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle.

by Fernando de M Dossin, Alexandre Dufour, Elodie Dusch, Jair L Siqueira-Neto, Carolina B Moraes, Gyong Seon Yang, Maria Isabel Cano, Auguste Genovesio, Lucio H Freitas-Junior
Published 2008-01-01

Design, Synthesis and Structure—Activity Relationships of a Phenotypic Small Library against Protozoan Infections

by Elisa Uliassi, Lorna Piazzi, Federica Belluti, Marcel Kaiser, Reto Brun, Sheraz Gul, Bernhard Ellinger, Carolina B. Moraes, Lucio H. Freitas-Junior, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Published 2017-10-01

Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.

by Deu John M Cruz, Rafaela M Bonotto, Rafael G B Gomes, Camila T da Silva, Juliana B Taniguchi, Joo Hwan No, Benoit Lombardot, Olivier Schwartz, Michael A E Hansen, Lucio H Freitas-Junior
Published 2013-01-01

Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection.

by Auguste Genovesio, Miriam A Giardini, Yong-Jun Kwon, Fernando de Macedo Dossin, Seo Yeon Choi, Nam Youl Kim, Hi Chul Kim, Sung Yong Jung, Sergio Schenkman, Igor C Almeida, Neil Emans, Lucio H Freitas-Junior
Published 2011-01-01

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.

by Jair L Siqueira-Neto, Ok-Ryul Song, Hyunrim Oh, Jeong-Hun Sohn, Gyongseon Yang, Jiyoun Nam, Jiyeon Jang, Jonathan Cechetto, Chang Bok Lee, Seunghyun Moon, Auguste Genovesio, Eric Chatelain, Thierry Christophe, Lucio H Freitas-Junior
Published 2010-01-01

From Live Cells to Caenorhabditis elegans: Selective Staining and Quantification of Lipid Structures Using a Fluorescent Hybrid Benzothiadiazole Derivative

by Alberto A. R. Mota, Jose R. Correa, Lorena P. de Andrade, José A. F. Assumpção, Giovana A. de Souza Cintra, Lucio H. Freitas-Junior, Wender A. da Silva, Heibbe C. B. de Oliveira, Brenno A. D. Neto
Published 2018-04-01

Amazonian Plant Natural Products: Perspectives for Discovery of New Antimalarial Drug Leads

by Lucio H. Freitas-Junior, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Carolina Borsoi Moraes, Gina Frausin, Luiz Francisco Rocha e Silva, Stefanie Costa Pinto Lopes, Renata Braga Souza Lima, Fabio Trindade Maranhão Costa, Adrian Martin Pohlit
Published 2013-08-01

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

by Caio H. Franco, David C. Warhurst, Tapan Bhattacharyya, Ho Y.A. Au, Hai Le, Miriam A. Giardini, Bruno S. Pascoalino, Ana Claudia Torrecilhas, Lavinia M.D. Romera, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, Michael A. Miles, Carolina B. Moraes
Published 2020-08-01

An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway.

by Mariana Serpeloni, Carolina Borsoi Moraes, João Renato Carvalho Muniz, Maria Cristina Machado Motta, Augusto Savio Peixoto Ramos, Rafael Luis Kessler, Alexandre Haruo Inoue, Wanderson Duarte daRocha, Sueli Fumie Yamada-Ogatta, Stenio Perdigão Fragoso, Samuel Goldenberg, Lucio H Freitas-Junior, Andréa Rodrigues Avila
Published 2011-01-01

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, <i>Boana raniceps</i>

by Carlos José Correia Santana, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Diego A. Falico, Agenor C. M. dos Santos Júnior, Beatriz D. Lima, Carlos André Ornelas Ricart, Denise Regina Bairros de Pilger, Rafaela Milan Bonotto, Carolina Borsoi Moraes, Lúcio H. Freitas-Júnior, Alice da Cunha Morales Álvares, Sonia Maria Freitas, Isabelle S. Luz, Osmindo Rodrigues Pires Jr., Wagner Fontes, Mariana S. Castro
Published 2020-05-01

In vitro and in vivo experimental models for drug screening and development for Chagas disease

by Alvaro José Romanha, Solange Lisboa de Castro, Maria de Nazaré Correia Soeiro, Joseli Lannes-Vieira, Isabela Ribeiro, André Talvani, Bernadette Bourdin, Bethania Blum, Bianca Olivieri, Carlos Zani, Carmenza Spadafora, Egler Chiari, Eric Chatelain, Gabriela Chaves, José Eduardo Calzada, Juan Manuel Bustamante, Lucio H Freitas-Junior, Luz I Romero, Maria Terezinha Bahia, Michel Lotrowska, Milena Soares, Sonia Gumes Andrade, Tanya Armstrong, Wim Degrave, Zilton de Araújo Andrade
Published 2010-03-01

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

by Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Published 2017-09-01