A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

by Laura M. Alcântara, Thalita C. S. Ferreira, Vanessa Fontana, Eric Chatelain, Carolina B. Moraes, Lucio H. Freitas-Junior
Published 2020-05-01

Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

by Bianca Zingales, Michael A Miles, Carolina B Moraes, Alejandro Luquetti, Felipe Guhl, Alejandro G Schijman, Isabela Ribeiro
Published 2014-09-01

Eletroforese capilar acoplada à espectrometria com plasma: uma ferramenta eficiente para a especiação Capillary electrophoresis coupled to plasma spectrometry: an efficient tool fo...

by Ana Paula G. Gervasio, André F. Lavorante, Maria Carolina B. Moraes, Maria Fernanda Giné, Carlos E. S. Miranda, Emanuel Carrilho
Published 2003-01-01

Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum.

by Carolina B Moraes, Thierry Dorval, Mónica Contreras-Dominguez, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lucio H Freitas-Junior
Published 2013-01-01

Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle.

by Fernando de M Dossin, Alexandre Dufour, Elodie Dusch, Jair L Siqueira-Neto, Carolina B Moraes, Gyong Seon Yang, Maria Isabel Cano, Auguste Genovesio, Lucio H Freitas-Junior
Published 2008-01-01

Design, Synthesis and Structure—Activity Relationships of a Phenotypic Small Library against Protozoan Infections

by Elisa Uliassi, Lorna Piazzi, Federica Belluti, Marcel Kaiser, Reto Brun, Sheraz Gul, Bernhard Ellinger, Carolina B. Moraes, Lucio H. Freitas-Junior, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Published 2017-10-01

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

by Caio H. Franco, David C. Warhurst, Tapan Bhattacharyya, Ho Y.A. Au, Hai Le, Miriam A. Giardini, Bruno S. Pascoalino, Ana Claudia Torrecilhas, Lavinia M.D. Romera, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, Michael A. Miles, Carolina B. Moraes
Published 2020-08-01

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

by Marjorie C. L. C. Freire, Gabriela D. Noske, Natália V. Bitencourt, Paulo R. S. Sanches, Norival A. Santos-Filho, Victor O. Gawriljuk, Eduardo P. de Souza, Victor H. R. Nogueira, Mariana O. de Godoy, Aline M. Nakamura, Rafaela S. Fernandes, Andre S. Godoy, Maria A. Juliano, Bianca M. Peres, Cecília G. Barbosa, Carolina B. Moraes, Lucio H. G. Freitas-Junior, Eduardo M. Cilli, Rafael V. C. Guido, Glaucius Oliva
Published 2021-08-01

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

by Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Published 2017-09-01