Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

by Alice Dawson, Paul Trumper, Juliana Oliveira de Souza, Holly Parker, Mathew J. Jones, Tim G. Hales, William N. Hunter
Published 2019-11-01

Dementia and mild cognitive impairment in prisoners aged over 50 years in England and Wales: a mixed-methods study

by Katrina Forsyth, Leanne Heathcote, Jane Senior, Baber Malik, Rachel Meacock, Katherine Perryman, Sue Tucker, Rachel Domone, Matthew Carr, Helen Hayes, Roger Webb, Laura Archer-Power, Alice Dawson, Sarah Leonard, David Challis, Stuart Ware, Richard Emsley, Caroline Sanders, Salman Karim, Seena Fazel, Adrian Hayes, Alistair Burns, Mary Piper, Jenny Shaw
Published 2020-06-01

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

by Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi
Published 2017-09-01