A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology.

A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology.

Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The lack of in vivo models of c...

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Bibliographic Details
Main Authors: Matteo M Trucco, Ola Awad, Breelyn A Wilky, Seth D Goldstein, Ruili Huang, Robert L Walker, Preeti Shah, Varalakshmi Katuri, Naheed Gul, Yuelin J Zhu, Edward F McCarthy, Ido Paz-Priel, Paul S Meltzer, Christopher P Austin, Menghang Xia, David M Loeb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3819300?pdf=render

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http://europepmc.org/articles/PMC3819300?pdf=render

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