(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming growth factor β (TGF-β) and profibrotic factors connecting ti...

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Bibliographic Details
Main Authors: Cristian Reyes-Martinez, Quynh My Nguyen, Modar Kassan, Alexis A. Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
(Pro)renin receptor
cyclooxygenase inhibition
reactive oxygen species
intrarenal renin–angiotensin system
collecting duct renin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00803/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00803/full

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