Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent Glioblastoma

Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent Glioblastoma

<b>Background:</b> Inevitable recurrence after radiochemotherapy is the major problem in the treatment of glioblastoma, the most prevalent type of adult brain malignancy. Glioblastomas are notorious for a high degree of intratumor heterogeneity manifest through a diversity of cell types...

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Main Authors: Ella L. Kim, Maxim Sorokin, Sven Rainer Kantelhardt, Darius Kalasauskas, Bettina Sprang, Julian Fauss, Florian Ringel, Andrew Garazha, Eugene Albert, Nurshat Gaifullin, Christian Hartmann, Nicole Naumann, Sven-Ernö Bikar, Alf Giese, Anton Buzdin
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
glioblastoma
glioblastoma stem cells
transcriptomics
recurrent glioblastoma
gene expression
target anti-cancer therapy
molecular pathways
Online Access:https://www.mdpi.com/2072-6694/12/2/520

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https://www.mdpi.com/2072-6694/12/2/520

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