Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Abstract Background Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. Methods We develop...

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Bibliographic Details
Main Authors: Zeran Li, Jorge L. Del-Aguila, Umber Dube, John Budde, Rita Martinez, Kathleen Black, Qingli Xiao, Nigel J. Cairns, The Dominantly Inherited Alzheimer Network (DIAN), Joseph D. Dougherty, Jin-Moo Lee, John C. Morris, Randall J. Bateman, Celeste M. Karch, Carlos Cruchaga, Oscar Harari
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Genome Medicine
Subjects:
Digital deconvolution
Alzheimer’s disease
Brain cellular composition
Bulk RNA-sequencing
Autosomal dominant AD
TREM2
Online Access:http://link.springer.com/article/10.1186/s13073-018-0551-4

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http://link.springer.com/article/10.1186/s13073-018-0551-4

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