Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies.

Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies.

In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydrazone derivatives (1a-k) intended for use as inhibitors of tumor necrosis factor alpha (TNF-α) production. The compounds were designed based on the orally active anti-inflamm...

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Bibliographic Details
Main Authors: Renata B Lacerda, Natália M Sales, Leandro L da Silva, Roberta Tesch, Ana Luisa P Miranda, Eliezer J Barreiro, Patricia D Fernandes, Carlos A M Fraga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3954757?pdf=render

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http://europepmc.org/articles/PMC3954757?pdf=render

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