Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

Abstract Growth factor deficiency in adulthood constitutes a distinct clinical syndrome with significant morbidities including abnormal body composition, reduced energy, affective disturbances, dyslipidemia, and increased cardiovascular risk. Protein replacement therapies using recombinant proteins...

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Bibliographic Details
Main Authors: Pingdong Tao, Yuanyuan Kuang, Yu Li, Wenping Li, Zibei Gao, Lili Liu, Min Qiang, Zhao Zha, Kun Fan, Peixiang Ma, Jeffrey M. Friedman, Guang Yang, Richard A. Lerner
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Advanced Science
Subjects:
combinatorial antibody library
full agonists
function‐guided selection
leptin receptors
replacement therapy
Online Access:https://doi.org/10.1002/advs.202000818

Internet

https://doi.org/10.1002/advs.202000818

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