Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides

Overlapping Properties of the Short Membrane-Active Peptide BP100 With (i) Polycationic TAT and (ii) α-helical Magainin Family Peptides

BP100 is a short, designer-made membrane-active peptide with multiple functionalities: antimicrobial, cell-penetrating, and fusogenic. Consisting of five lysines and 6 hydrophobic residues, BP100 was shown to bind to lipid bilayers as an amphipathic α-helix, but its mechanism of action remains uncle...

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Bibliographic Details
Main Authors: Christian Mink, Erik Strandberg, Parvesh Wadhwani, Manuel N. Melo, Johannes Reichert, Irene Wacker, Miguel A. R. B. Castanho, Anne S. Ulrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
short multifunctional peptide BP100
cationic amphipathic α-helix
membranolytic and cell-penetrating mechanisms
antimicrobial activity
hemolysis
vesicle fusion
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.609542/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.609542/full

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