Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Abstract Background Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA binding protein 8 (CHD8), a gene encoding a chromatin remodeler. It ha...

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Bibliographic Details
Main Authors: Stanislav M. Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I. Nakayama, Masaaki Nishiyama, Haruhiro Higashida
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Neuroscience
Subjects:
Autism
Oxytocin
CHD8
Social novelty
Anxiety
Online Access:https://doi.org/10.1186/s12868-021-00631-6

Internet

https://doi.org/10.1186/s12868-021-00631-6

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