Millisecond Timescale Motions Connect Amino Acid Interaction Networks in Alpha Tryptophan Synthase

Tryptophan synthase is a model system for understanding allosteric regulation within enzyme complexes. Amino acid interaction networks were previously delineated in the isolated alpha subunit (αTS) in the absence of the beta subunit (βTS). The amino acid interaction networks were different between t...

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Bibliographic Details
Main Authors: Kathleen F. O'Rourke, Jennifer M. Axe, Rebecca N. D'Amico, Debashish Sahu, David D. Boehr
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Biosciences
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Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00092/full