The Picornavirus Precursor 3CD has Different Conformational Dynamics Compared to 3C^pro and 3D^pol in Functionally Relevant Regions

by Dennis S. Winston, David D. Boehr
Published 2021-03-01

Controlling Active Site Loop Dynamics in the (β/α)8 Barrel Enzyme Indole-3-Glycerol Phosphate Synthase

by Kathleen F. O’Rourke, Aneta M. Jelowicki, David D. Boehr
Published 2016-08-01

Biophysical and computational methods to analyze amino acid interaction networks in proteins

by Kathleen F. O'Rourke, Scott D. Gorman, David D. Boehr
Published 2016-01-01

Millisecond Timescale Motions Connect Amino Acid Interaction Networks in Alpha Tryptophan Synthase

by Kathleen F. O'Rourke, Jennifer M. Axe, Rebecca N. D'Amico, Debashish Sahu, David D. Boehr
Published 2018-11-01

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

by Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr
Published 2015-10-01

Substitution of a Surface-Exposed Residue Involved in an Allosteric Network Enhances Tryptophan Synthase Function in Cells

by Rebecca N. D’Amico, Yuliana K. Bosken, Kathleen F. O’Rourke, Alec M. Murray, Woudasie Admasu, Chia-en A. Chang, David D. Boehr
Published 2021-05-01

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

by Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M De Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris De Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D Boehr, Jamie J Arnold, Craig E Cameron, Nuria Verdaguer, Johan Neyts, Frank J M van Kuppeveld
Published 2015-03-01