Generation and Neuronal Differentiation of hiPSCs From Patients With Myotonic Dystrophy Type 2

Generation and Neuronal Differentiation of hiPSCs From Patients With Myotonic Dystrophy Type 2

Human induced pluripotent stem cells (hiPSCs)-patient specific are an innovative tool to reproduce a model of disease in vitro and summarize the pathological phenotype and the disease etiopathology. Myotonic dystrophy type 2 (DM2) is caused by an unstable (CCTG)n expansion in intron 1 of the CNBP ge...

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Bibliographic Details
Main Authors: Paola Spitalieri, Rosa V. Talarico, Michela Murdocca, Luana Fontana, Marzia Marcaurelio, Elena Campione, Roberto Massa, Giovanni Meola, Annalucia Serafino, Giuseppe Novelli, Federica Sangiuolo, Annalisa Botta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
myotonic dystrophy type 2 (DM2)
human induced pluripotent stem cells (hiPSCs)
intranuclear foci
neuronal population (NP)
muscleblind-like 1 and 2 (MBNL1 and 2)
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00967/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00967/full

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