Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

Summary: A hallmark of acute myeloid leukemia (AML) is the inability of self-renewing malignant cells to mature into a non-dividing terminally differentiated state. This differentiation block has been linked to dysregulation of multiple cellular processes, including transcriptional, chromatin, and m...

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Bibliographic Details
Main Authors: Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
molecular biology
stem cell research
systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006192

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http://www.sciencedirect.com/science/article/pii/S2589004221006192

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