Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

Radiotherapy is a commonly used conditioning regimen for bone marrow transplantation (BMT). Cytotoxicity limits the use of this life-saving therapy, but the underlying mechanisms remain poorly defined. Here, we use the syngeneic mouse BMT model to test the hypothesis that lethal radiation damages ti...

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Bibliographic Details
Main Authors: Jianqiu Xiao, Chun Wang, Juo-Chin Yao, Yael Alippe, Tong Yang, Dustin Kress, Kai Sun, Kourtney L Kostecki, Joseph B Monahan, Deborah J Veis, Yousef Abu-Amer, Daniel C Link, Gabriel Mbalaviele
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000807

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https://doi.org/10.1371/journal.pbio.3000807

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