Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer

Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer

Abstract Background Limited understanding of the cancer biology of metastatic sites is a major factor contributing to poor outcomes in cancer patients. The regional lymph nodes are the most common site of metastasis in most solid cancers and their involvement is a strong predictor of relapse in brea...

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Bibliographic Details
Main Authors: Abdi Ghaffari, Victoria Hoskin, Gulisa Turashvili, Sonal Varma, Jeff Mewburn, Graeme Mullins, Peter A. Greer, Friedemann Kiefer, Andrew G. Day, Yolanda Madarnas, Sandip SenGupta, Bruce E. Elliott
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Breast Cancer Research
Subjects:
Ezrin
Quantitative intravital imaging
Cell migration
Lymph node metastasis
Biomarker
Metastatic disease
Online Access:http://link.springer.com/article/10.1186/s13058-018-1079-7

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http://link.springer.com/article/10.1186/s13058-018-1079-7

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