Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43

Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43

TAR DNA-binding protein 43 (TDP-43) is a 414-residue long nuclear protein whose deposition into intraneuronal insoluble inclusions has been associated with the onset of amyotrophic lateral sclerosis (ALS) and other diseases. This protein is physiologically a homodimer, and dimerization occurs throug...

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Bibliographic Details
Main Authors: Mirella Vivoli-Vega, Prandvera Guri, Fabrizio Chiti, Francesco Bemporad
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
folding intermediate
misfolding
self-assembly
neurodegeneration
proteinopathy
Online Access:https://www.mdpi.com/1422-0067/21/17/6259

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https://www.mdpi.com/1422-0067/21/17/6259

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