Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial

Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial

Abstract Objectives SARS-Cov-2 virus preferentially binds to the Angiotensin Converting Enzyme 2 (ACE2) on alveolar epithelial type II cells, initiating an inflammatory response and tissue damage which may impair surfactant synthesis contributing to alveolar collapse, worsening hypoxia and leading t...

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Bibliographic Details
Main Authors: Ahilanandan Dushianthan, Howard Clark, Jens Madsen, Robin Mogg, Lewis Matthews, Lee Berry, Jorge Bernardino de la Serna, James Batchelor, David Brealey, Tracy Hussell, Joanna Porter, Ratko Djukanovic, Martin Feelisch, Anthony Postle, Michael P. W. Grocott
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Trials
Subjects:
COVID-19
Randomised controlled trial
protocol
surfactant
Intensive Care
mechanical ventilation
Online Access:https://doi.org/10.1186/s13063-020-04944-5

Internet

https://doi.org/10.1186/s13063-020-04944-5

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