Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal choles...

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Bibliographic Details
Main Authors: André J. Tremblay, Benoît Lamarche, Valéry Lemelin, Lizbeth Hoos, Suzanne Benjannet, Nabil G. Seidah, Jr. Harry R. Davis, Patrick Couture
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick C1-like 1
cholesterol metabolism
3-hydroxy-3-methylglutaryl CoA reductase
intestine
low density lipoprotein receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409368

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http://www.sciencedirect.com/science/article/pii/S0022227520409368

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