Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-pathway gene expression in pulmonary fibrobla...

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Bibliographic Details
Main Authors: Hoeke A Baarsma, Anita I R Spanjer, Gertruud Haitsma, Lilian H J M Engelbertink, Herman Meurs, Marnix R Jonker, Wim Timens, Dirkje S Postma, Huib A M Kerstjens, Reinoud Gosens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3184127?pdf=render

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http://europepmc.org/articles/PMC3184127?pdf=render

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