Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-<i>N</i>-Acylhydrazone Derivative

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-<i>N</i>-Acylhydrazone Derivative

Pulmonary arterial hypertension (PAH) is a chronic cardiovascular disease that displays inflammatory components, which contributes to the difficulty of adequate treatment with the available therapeutic arsenal. In this context, the <i>N</i>-acylhydrazone derivative LASSBio-1359 was previ...

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Bibliographic Details
Main Authors: Isadora T. S. Bastos, Pedro de Sena M. Pinheiro, Fanny N. Costa, Miguel D. Rocha, Carlos Mauricio R. Sant’Anna, Delson Braz, Everton T. Souza, Marco A. Martins, Eliezer J. Barreiro, Fabio F. Ferreira, Regina C. Barroso, Carlos A. M. Fraga
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceuticals
Subjects:
<i>N</i>-acylhydrazone
PDE4 inhibitor
adenosine A<sub>2A</sub> receptor
X-ray powder diffractometry
crystal structure determination
chalcogen bond
sigma-hole
Online Access:https://www.mdpi.com/1424-8247/11/4/119

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https://www.mdpi.com/1424-8247/11/4/119

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