E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

TraR and its homolog DksA are bacterial proteins that regulate transcription initiation by binding directly to RNA polymerase (RNAP) rather than to promoter DNA. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remain...

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Bibliographic Details
Main Authors: James Chen, Saumya Gopalkrishnan, Courtney Chiu, Albert Y Chen, Elizabeth A Campbell, Richard L Gourse, Wilma Ross, Seth A Darst
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
cryo-electron microscopy
RNA polymerase
transcription initiation
TraR
Online Access:https://elifesciences.org/articles/49375

Internet

https://elifesciences.org/articles/49375

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