Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation

Abstract Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations are thought to be a rare cause of neuronal ceroid lipofuscinosis (NCL). Aged progranu...

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Bibliographic Details
Main Authors: Terri L. Petkau, Natalia Kosior, Kathleen de Asis, Colúm Connolly, Blair R. Leavitt
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Neuroinflammation
Subjects:
Frontotemporal lobar degeneration
Neuronal ceroid lipofuscinosis
Progranulin
Conditional knockout mice
Neuropathology
Lysozyme promotor
Online Access:http://link.springer.com/article/10.1186/s12974-017-1000-9

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http://link.springer.com/article/10.1186/s12974-017-1000-9

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