Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. However, oximes also bind to the active site of ACh...

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Bibliographic Details
Main Authors: Kamil Kuca, Brian J. Bennion, Rafael Dolezal, Filip Zemek, Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
oximes
acetylcholinesterase
inhibitors
SAR study
Online Access:http://www.mdpi.com/1422-0067/14/8/16882

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http://www.mdpi.com/1422-0067/14/8/16882

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