Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.

Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils is a well-established hallmark of Alzheimer's disease, the complex mechanisms linking this process to neurodegeneration are still incompletely understood. The nematode worm C. elegans is a valuable model organism throug...

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Bibliographic Details
Main Authors: Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217746