Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

Objective: Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compensatory metabolic programmes that modulate non-alc...

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Bibliographic Details
Main Authors: Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Metabolism
Subjects:
Non-alcoholic fatty liver disease (NAFLD)
De novo lipogenesis (DNL)
Lipid remodelling
Western diet
Carbon tetrachloride (CCl4)
Liver regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000508

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http://www.sciencedirect.com/science/article/pii/S2212877821000508

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