Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

Human embryonic stem cells (hESCs) were used as a model system of human pancreas development to study characteristics of the polyhormonal cells that arise during fetal pancreas development. HESCs were differentiated into fetal-like pancreatic cells in vitro using a 33-day, 7-stage protocol. Cultures...

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Bibliographic Details
Main Authors: Jennifer E. Bruin, Suheda Erener, Javier Vela, Xiaoke Hu, James D. Johnson, Harley T. Kurata, Francis C. Lynn, James M. Piret, Ali Asadi, Alireza Rezania, Timothy J. Kieffer
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506113001451