Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty acids to a glycerol backbone, with unique enzymes required to catalyze each acylation step. Acylation at the sn-2 position requires 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) activity. To date, seven...

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Bibliographic Details
Main Authors: Laurent Vergnes, Anne P. Beigneux, Ryan Davis, Steven M. Watkins, Stephen G. Young, Karen Reue
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Journal of Lipid Research
Subjects:
acyltransferase
gene-trap
adipose tissue
energy expenditure
1-acylglycerol-3-phosphate O-acyltransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332703

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http://www.sciencedirect.com/science/article/pii/S0022227520332703

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