Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats.

Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats.

Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes to the underlying mechanism. Therefore, new therapeutic strategies to attenuate the effects of MMP-9 are urgently needed. In the prese...

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Main Authors: Baohong Jiang, Defang Li, Yanping Deng, Fukang Teng, Jing Chen, Song Xue, Xiangqian Kong, Cheng Luo, Xu Shen, Hualiang Jiang, Feng Xu, Wengang Yang, Jun Yin, Yanhui Wang, Hui Chen, Wanying Wu, Xuan Liu, De-an Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3606118?pdf=render

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http://europepmc.org/articles/PMC3606118?pdf=render

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