Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease

Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease

We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer’s disease (LOAD). A ten plasma lipid panel, predicted phenoconversion and provided 90% sensitivity and 85% specificity in differentiating an at-risk group from those that would remain cognitively intact. Despite t...

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Bibliographic Details
Main Authors: Massimo S Fiandaca, Xioagang eZhong, Amrita K Cheema, Michael H. Orquiza, Swathi eChidambaram, Ming T Tan, Carole Roan Gresenz, Kevin T FitzGerald, Michael A Nalls, Andrew B Singleton, Mark eMapstone, Howard J Federoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Neurology
Subjects:
Economics
Ethics
Lipids
Metabolomics
Risk Assessment
biomarkers
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00237/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00237/full

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