Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain

Gene editing tools like TALENs, ZFNs and Crispr/Cas now offer unprecedented opportunities for targeted genetic manipulations in virtually all species. Most of the recent research in this area has concentrated on manipulation of the genome in isolated cells, which then give rise to transgenic animals...

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Bibliographic Details
Main Authors: Muzna Zahur, Johan Tolö, Mathias Bähr, Sebastian Kügler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00142/full