Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury

Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury

Mechanical ventilation is an essential lifesaving therapy in acute respiratory distress syndrome (ARDS) that may cause ventilator-induced lung injury (VILI) through a positive feedback between altered alveolar mechanics, edema, surfactant inactivation, and injury. Although the biophysical forces tha...

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Bibliographic Details
Main Authors: Bradford J. Smith, Gregory S. Roy, Alyx Cleveland, Courtney Mattson, Kayo Okamura, Chantel M. Charlebois, Katharine L. Hamlington, Michael V. Novotny, Lars Knudsen, Matthias Ochs, R. Duncan Hite, Jason H. T. Bates
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
ventilator-induced lung injury
stereology
pulmonary surfactant
lung function
alveolar mechanics
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00660/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00660/full

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