p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.

Bibliographic Details
Main Authors: Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian Y. H. Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A. Malagon, Patricia Valerio, Marcos F. Fondevila, Johan Fernø, Maria M. Malagon, Raian Contreras, Paul Pfluger, Jens C. Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05711-6

Internet

https://doi.org/10.1038/s41467-018-05711-6

Similar Items