p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05711-6 |
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doaj-e3abcb467c8540338b4c0581b476791c2021-05-11T09:51:25ZengNature Publishing GroupNature Communications2041-17232018-08-019111610.1038/s41467-018-05711-6p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1Mar Quiñones0Omar Al-Massadi1Cintia Folgueira2Stephan Bremser3Rosalía Gallego4Leonardo Torres-Leal5Roberta Haddad-Tóvolli6Cristina García-Caceres7Rene Hernandez-Bautista8Brian Y. H. Lam9Daniel Beiroa10Estrella Sanchez-Rebordelo11Ana Senra12Jose A. Malagon13Patricia Valerio14Marcos F. Fondevila15Johan Fernø16Maria M. Malagon17Raian Contreras18Paul Pfluger19Jens C. Brüning20Giles Yeo21Matthias Tschöp22Carlos Diéguez23Miguel López24Marc Claret25Peter Kloppenburg26Guadalupe Sabio27Ruben Nogueiras28Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaBiocenter, Institute for Zoology, University of CologneDepartment of Morphological Sciences, School of Medicine, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum MünchenDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s HospitalDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of BergenCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum MünchenInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum MünchenDepartment of Mouse Genetics and Metabolism, Institute for Genetics and Center for Molecular Medicine (CMMC), University of CologneMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s HospitalInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum MünchenDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaNeuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Biocenter, Institute for Zoology, University of CologneFundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIDepartment of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación SanitariaEmerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.https://doi.org/10.1038/s41467-018-05711-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras |
| spellingShingle |
Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 Nature Communications |
| author_facet |
Mar Quiñones Omar Al-Massadi Cintia Folgueira Stephan Bremser Rosalía Gallego Leonardo Torres-Leal Roberta Haddad-Tóvolli Cristina García-Caceres Rene Hernandez-Bautista Brian Y. H. Lam Daniel Beiroa Estrella Sanchez-Rebordelo Ana Senra Jose A. Malagon Patricia Valerio Marcos F. Fondevila Johan Fernø Maria M. Malagon Raian Contreras Paul Pfluger Jens C. Brüning Giles Yeo Matthias Tschöp Carlos Diéguez Miguel López Marc Claret Peter Kloppenburg Guadalupe Sabio Ruben Nogueiras |
| author_sort |
Mar Quiñones |
| title |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_short |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_full |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_fullStr |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_full_unstemmed |
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 |
| title_sort |
p53 in agrp neurons is required for protection against diet-induced obesity via jnk1 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity. |
| url |
https://doi.org/10.1038/s41467-018-05711-6 |
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