Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.

Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the predominant serotype 3 clone in much of the w...

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Bibliographic Details
Main Authors: Nicholas J Croucher, Andrea M Mitchell, Katherine A Gould, Donald Inverarity, Lars Barquist, Theresa Feltwell, Maria C Fookes, Simon R Harris, Janina Dordel, Susannah J Salter, Sarah Browall, Helena Zemlickova, Julian Parkhill, Staffan Normark, Birgitta Henriques-Normark, Jason Hinds, Tim J Mitchell, Stephen D Bentley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3794909?pdf=render

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http://europepmc.org/articles/PMC3794909?pdf=render

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