RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

Asthma is a chronic inflammatory disease. Although many patients with asthma develop type-2 dominated eosinophilic inflammation, a number of individuals develop paucigranulocytic asthma, which occurs in the absence of eosinophilia or neutrophilia. The aetiology of paucigranulocytic asthma is unknown...

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Bibliographic Details
Main Authors: Jaisy Arikkatt, Md Ashik Ullah, Kirsty Renfree Short, Vivan Zhang, Wan Jun Gan, Zhixuan Loh, Rhiannon B Werder, Jennifer Simpson, Peter D Sly, Stuart B Mazzone, Kirsten M Spann, Manuel AR Ferreira, John W Upham, Maria B Sukkar, Simon Phipps
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
asthma
paucigranulocytic
virus infection
RAGE
HMGB1
Online Access:https://elifesciences.org/articles/21199

Internet

https://elifesciences.org/articles/21199

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