Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity

Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity

Abstract Expression quantitative trait loci (eQTLs) identified using tumor gene expression data could affect gene expression in cancer cells, tumor-associated normal cells, or both. Here, we have demonstrated a method to identify eQTLs affecting expression in cancer cells by modeling the statistical...

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Bibliographic Details
Main Authors: Paul Geeleher, Aritro Nath, Fan Wang, Zhenyu Zhang, Alvaro N. Barbeira, Jessica Fessler, Robert L. Grossman, Cathal Seoighe, R. Stephanie Huang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
Expression quantitative trait locus (eQTL)
Genome-wide association study (GWAS)
Cancer
Gene regulation
Deconvolution
Online Access:http://link.springer.com/article/10.1186/s13059-018-1507-0

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http://link.springer.com/article/10.1186/s13059-018-1507-0

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