Reduced oxidative capacity in macrophages results in systemic insulin resistance

Reduced oxidative capacity in macrophages results in systemic insulin resistance

M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be rever...

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Bibliographic Details
Main Authors: Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W. Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03998-z

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https://doi.org/10.1038/s41467-018-03998-z

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