Insights into Diphthamide, Key Diphtheria Toxin Effector

Insights into Diphthamide, Key Diphtheria Toxin Effector

Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7. In an effort to further study diphthamide synthe...

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Bibliographic Details
Main Authors: Raffael Schaffrath, Michael J. R. Stark, Shanow Uthman, Viktor Scheidt, Wael Abdel-Fattah
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Toxins
Subjects:
diphtheria toxin
sordarin
diphthamide biosynthesis
DPH1-DPH7 genes
Online Access:http://www.mdpi.com/2072-6651/5/5/958

Internet

http://www.mdpi.com/2072-6651/5/5/958

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