The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac mortality. The molecular pathways in the induction of pressure overload LVH are potential targets for therapeutic intervention. Current treatmen...

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Bibliographic Details
Main Authors: Yang Guo, Ze-Yan Yu, Jianxin Wu, Hutao Gong, Scott Kesteven, Siiri E Iismaa, Andrea Y Chan, Sara Holman, Silvia Pinto, Andy Pironet, Charles D Cox, Robert M Graham, Rudi Vennekens, Michael P Feneley, Boris Martinac
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
mechanosensitive channels
left ventricular hypertrophy
cardiovascular disease
Ca2+/calmodulin-dependent protein kinase II
Online Access:https://elifesciences.org/articles/66582

Internet

https://elifesciences.org/articles/66582

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