Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1

Chronic pain is an undertreated epidemic affecting quality of life in at least 20% of the global population, and CNS-related side effects, tolerance, and addiction are common features of current medications. α-Conotoxin Vc1.1 potently elicits prolonged analgesia in preclinical chronic constriction i...

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Bibliographic Details
Main Authors: Aaron G. Poth, Francis C.K. Chiu, Sofie Stalmans, Brett R. Hamilton, Yen-Hua Huang, David M. Shackleford, Rahul Patil, Thao T. Le, Meng-Wei Kan, Thomas Durek, Evelien Wynendaele, Bart De Spiegeleer, Andrew K. Powell, Deon J. Venter, Richard J. Clark, Susan A. Charman, David J. Craik
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Medicine in Drug Discovery
Subjects:
conotoxin
cyclic peptides
pharmacokinetics
bioavailability
drug efficiency index
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098621000087

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http://www.sciencedirect.com/science/article/pii/S2590098621000087

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