T cell-intrinsic role of IL-6 signaling in primary and memory responses

T cell-intrinsic role of IL-6 signaling in primary and memory responses

Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood. In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor α chain (IL-6Rα) results in impaired Th1 and Th17 T cell responses...

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Bibliographic Details
Main Authors: Simone A Nish, Dominik Schenten, F Thomas Wunderlich, Scott D Pope, Yan Gao, Namiko Hoshi, Shuang Yu, Xiting Yan, Heung Kyu Lee, Lesley Pasman, Igor Brodsky, Brian Yordy, Hongyu Zhao, Jens Brüning, Ruslan Medzhitov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
cytokine
t cell
regulatory T cell
memory
Online Access:https://elifesciences.org/articles/01949

Internet

https://elifesciences.org/articles/01949

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