Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development

In this study, we determined if BRCA1 partners involved in DNA double-strand break (DSB) and mismatch repair (MMR) may contribute to breast and ovarian cancer development. Taking advantage the functional conservation of DNA repair pathways between yeast and human, we expressed several BRCA1 missense...

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Bibliographic Details
Main Authors: Luisa Maresca, Samuele Lodovichi, Alessandra Lorenzoni, Tiziana Cervelli, Rossella Monaco, Laura Spugnesi, Mariella Tancredi, Elisabetta Falaschi, Katia Zavaglia, Elisabetta Landucci, Manuela Roncella, Caterina Congregati, Angiolo Gadducci, Antonio Giuseppe Naccarato, Maria Adelaide Caligo, Alvaro Galli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Genetics
Subjects:
BRCA1 missense variants
DNA repair genes
yeast based-functional assay
breast and ovarian cancer
somatic variants
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00397/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00397/full

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