Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Abstract Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly developed therapies partially restore dystrophin expressio...

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Bibliographic Details
Main Authors: Gerard A. Marchal, Maaike van Putten, Arie O. Verkerk, Simona Casini, Kayleigh Putker, Shirley C. M. van Amersfoorth, Annemieke Aartsma-Rus, Elisabeth M. Lodder, Carol Ann Remme
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89208-1

Internet

https://doi.org/10.1038/s41598-021-89208-1

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