Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies

Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies

Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been largely demonstrated to contribute to PCa progression. Diverse naturally occurring compounds and dietary supplements are endowed with anti-oxid...

Full description

Bibliographic Details
Main Authors: Denisa Baci, Antonino Bruno, Caterina Cascini, Matteo Gallazzi, Lorenzo Mortara, Fausto Sessa, Giuseppe Pelosi, Adriana Albini, Douglas M. Noonan
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Carnitine
Prostate cancer
Angiogenesis
Inflammation
Angioprevention
Chemoprevention
Online Access:http://link.springer.com/article/10.1186/s13046-019-1461-z

Internet

http://link.springer.com/article/10.1186/s13046-019-1461-z

Similar Items