Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

Hyper-active GSK-3β favors Tau phosphorylation during the progression of Alzheimer's disease (AD). Akt is one of the main kinases inhibiting GSK-3β and its activation occurs in response to neurotoxic stimuli including, i.e., oxidative stress. Biliverdin reductase-A (BVR-A) is a scaffold protein...

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Bibliographic Details
Main Authors: Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Barone
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Akt
Biliverdin reductase-A
GSK-3β
Oxidative stress
Tau phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300348

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http://www.sciencedirect.com/science/article/pii/S0969996119300348

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