Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.
Accurate molecular diagnosis of monogenic non-autoimmune neonatal diabetes mellitus (NDM) is critical for patient care, as patients carrying a mutation in KCNJ11 or ABCC8 can be treated by oral sulfonylurea drugs instead of insulin therapy. This diagnosis is currently based on Sanger sequencing of a...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-10-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2964316?pdf=render |