LRRK2 Phosphorylation, More Than an Epiphenomenon

LRRK2 Phosphorylation, More Than an Epiphenomenon

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are associated with an increased risk for sporadic PD. This gene encodes a kinase that is physiologically multiphosphorylated, includin...

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Bibliographic Details
Main Authors: Antoine Marchand, Matthieu Drouyer, Alessia Sarchione, Marie-Christine Chartier-Harlin, Jean-Marc Taymans
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
LRRK2
phosphorylation
Parkinson's disease
kinase
phosphatase
phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00527/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00527/full

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