Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.

Improved molecular diagnostic methods for detection drug resistance in Mycobacterium tuberculosis (MTB) strains are required. Resistance to first- and second- line anti-tuberculous drugs has been associated with single nucleotide polymorphisms (SNPs) in particular genes. However, these SNPs can vary...

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Bibliographic Details
Main Authors: Asho Ali, Zahra Hasan, Ruth McNerney, Kim Mallard, Grant Hill-Cawthorne, Francesc Coll, Mridul Nair, Arnab Pain, Taane G Clark, Rumina Hasan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4342168?pdf=render